Tag Archives: Dr Gorbach

Lyme Disease DNA Testing

Jan 17, 2014

Clinical Infectious Diseases

Editor-in-Chief, Sherwood L. Gorbach, M.D

Dear Dr Gorbach,

The Molecular Diagnostics Department of Milford Medical Laboratory recently announced a DNA Sequencing-based diagnostic test for Borrelia burgdorferi and Borrelia miyamotoi.

BREAKING NEWS: Jan. 15, 2014 – BusinessWire Press Release

Lyme Disease DNA Testing

http://www.dnalymetest.com/faq.html

Statement from Milford Medical Laboratory:

“……spirochetes will not stay in the blood of the patient for long because they prefer to live in the deep tissues, such as the joints, the heart and the nervous system. The window of opportunity to find the spirochetes in the blood is narrow….”

In reference to Dr Alan Steere’s study recently published in Clinical Infectious Diseases I would like to point out the following statements from his study:

“….all post-treatment culture results were negative…”

“….suggesting that spirochetal eradication had occurred with treatment in all patients.”

So is Dr Alan Steere not aware that the “spirochetes will not stay in the blood of the patient for long” or has he rushed to conclusion here to support his renowned bias against persistent infection as I highlighted in my letter to the editor?

I would like to point out a recent article found in Forbes:

Medicine Or Mass Murder? Guideline Based on Discredited Research May Have Caused 800,000 Deaths In Europe Over The Last 5 Years

http://www.forbes.com/sites/larryhusten/2014/01/15/medicine-or-mass-murder-guideline-based-on-discredited-research-may-have-caused-800000-deaths-in-europe-over-the-last-5-years/

The article focuses on the damage caused by the disgraced Dutch cardiovascular researcher Don Poldermans who was fired for scientific misconduct. A follow-up article will focus on the institutional leaders who provided uncritical support as well as the role of journal editors in this case.

A comment following the article struck a chord with me:

“There is, it has now become clear, a general lack of concern and response to evidence of scientific fraud and misconduct. Journal editors, deans, department chairs, and others seem more concerned with protecting the reputation of their respective institutions than aggressively upholding the integrity of science and research.”

Dr Gorbach…… per your reply to me, one of the reasons you decided not to publish my letter to the editor was as follows: “it represents a personal, not a scientific, attack on Dr. Steere…” It would appear that reputation overrides integrity.

Spinning the data to support one’s bias jeopardizes the integrity of the Journal in which the research is published. Dr Alan Steere holds steadfast to the idea that he can fool all of the people all of the time with authorization to do so.

Sincerely,

Carl Tuttle

Hudson, NH 03051

A Systematic Review of Borrelia burgdorferi Morphologic Variants Does Not Support a Role in Chronic Lyme Disease

From: “Carl Tuttle” <runagain@comcast.net>
To: “Clinical Infectious Diseases” <cid@tufts.edu>
Cc: cid3@tufts.edu, CID-editor@tufts.edu, “sherwood gorbach” <sherwood.gorbach@tufts.edu>, “michael barza” <michael.barza@tufts.edu>, scosgro1@jhmi.edu, asteere@partners.org, kstrle@partners.org,ethics@harvard.edu,

“David Linsky” <David.Linsky@mahouse.gov>, “Dick Blumenthal” <Dick_Blumenthal@blumenthal.senate.gov>

To: “Clinical Infectious Diseases” <cid@tufts.edu>

Sent: Sunday, December 15, 2013 11:26:22 PM

Subject: Re: CID MS 73416

Dear Dr Gorbach,

Here is yet another example of junk science published in Clinical Infectious Diseases aimed at denying the existence of persistent infection.

A Systematic Review of Borrelia burgdorferi Morphologic Variants Does Not Support a Role in Chronic Lyme Disease

http://cid.oxfordjournals.org/content/early/2013/12/12/cid.cit810.abstract

Conclusion from the “Three Amigos” abstract: (Lantos, Auwaerter and Wormser)

Conclusions.”In the context of the broader medical literature it is not currently possible to ascribe a pathogenic role to morphologic variants of  B. burgdorferi in either typical manifestations of Lyme disease or in other chronic disease states that are often labeled chronic Lyme disease. There is no clinical literature to justify specific treatment of B. burgdorferi morphologic variants.”

Studies on the Cystic Form of Borrelia burgdorferi Mechanisms of Persistence

http://www.samento.com.ec/sciencelib/4lyme/studiesoncyst.pdf

Effects of Penicillin, Ceftriaxone, and Doxycycline on Morphology of Borrelia burgdorferi

Date of Publication: May, 1995

Source: Antimicrobial Agents & Chemotherapy, 39(5):1127-33

Authors: Kersten A; Poitschek C; Rauch S; Aberer E.

Institution: Department of Dermatology, University of Vienna, AustriaAbstract

Antibiotic therapy with penicillin, doxycycline, and ceftriaxone has proven to be effective for the treatment of Lyme borreliosis. In some patients, however, it was noticed that borreliae can survival in the tissues in spite of seemingly adequate therapy. For a better understanding of this phenomenon, we investigated the different modes of degeneration of Borrelia burgdorferi suspensions during a 96-h exposure to various antibiotics. By dark-field microscopy and ultrastructural investigations,increasing blebbing and the gradual formation of granular and cystic structures could be followed during the exposure time. Although antibiotic concentrations at the MIC at which 90% of organisms are inhibited after 72 h were 80% or even greater, motile organisms were still present after incubation with penicillin and doxycycline but not after incubation with ceftriaxone. By transmission electron microscopy, intact spirochetal parts, mostly situated in cysts, were seen up to 96 h after exposure with all three antibiotics tested. According to experiences from studies with other spirochetes it is suggested that encysted borreliae, granules, and the remaining blebs might be responsible for the ongoing antigenic stimulus leading to complaints of chronic Lyme borreliosis.

——————————————————

Quotation From The Full-Text Article

“Morphologically intact borrelia parts seen after 4 days of incubation with antibiotics, however, may also persist in humans during antibiotic treatment. …granules and encysted

B. burgdorferi should be investigated further in view of their long-term persistence in infected tissues and their contribution to the pathogenesis of Lyme borreliosis.” (p.1132)

Carl Tuttle

Website: New Hampshire Lyme Misdiagnosis